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Details on Person Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2

Class:Id	BlackBoxEvent:9676072
_displayName	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2
_doRelease	TRUE
_timestamp	2020-12-12 08:31:50
authored	[InstanceEdit:9675009] May, Bruce, 2020-01-29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9676073] May, Bruce, 2020-02-07
edited	[InstanceEdit:9675009] May, Bruce, 2020-01-29
input	[Complex:9674894] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:9609278] Hck [cytosol] [Mus musculus] [EntityWithAccessionedSequence:205743] Jak2 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:442293] Syk [cytosol] [Mus musculus] [EntityWithAccessionedSequence:1067666] Tyk2 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9676033] Aberrant activation of JAK/STAT pathway components in response to G-CSF, interferon-alpha/beta and interferon-gamma in NFS-60 cells [LiteratureReference:9676053] Dissociation of the Jak kinase pathway from G-CSF receptor signaling in neutrophils [LiteratureReference:9676040] Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK [LiteratureReference:9677145] The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor [LiteratureReference:9674566] Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases [LiteratureReference:9677140] The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal
modified	[InstanceEdit:9677157] May, Bruce, 2020-02-28 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2
output	[Complex:9676066] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 [plasma membrane] [Mus musculus]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9676074] R-MMU-9676072.2
summation	[Summation:9677150] The kinases Jak2 (Nicholson et al. 1995, Avalos et al. 1997)...
(inferredFrom)	[BlackBoxEvent:9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK [Homo sapiens]
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No pathways have been reviewed or authored by Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2 (9676072)