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Details on Person The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscl...
| Class:Id | Summation:9675995 |
|---|---|
| _displayName | The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscl... |
| _timestamp | 2020-02-06 16:48:30 |
| created | [InstanceEdit:9675996] Murillo, Julieth, 2020-02-06 |
| literatureReference | [LiteratureReference:375262] Characterization of the human cysteinyl leukotriene 2 receptor [LiteratureReference:416394] Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor [LiteratureReference:375250] Characterization of the human cysteinyl leukotriene CysLT1 receptor [LiteratureReference:9664536] Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion |
| text | The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cys-LT receptors, 1 (Lynch KR et al, 1999) and 2 (Heise CE et al, 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau HM et al, 1999). However, signalling downstream LTC4-cysLTR binding has been associated with the production of IL4, independent of the GPCR associated heterotrimeric protein Gq (Bandeira Melo et al. 2002). |
| (summation) | [Reaction:9664306] LTC4 binds CyslTR1,2 [Homo sapiens] |
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No pathways have been reviewed or authored by The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscl... (9675995)
