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Details on Person WDR5 and DPY30 interact with the RBBP5:ASH2L heterodimer and...

Class:IdSummation:9675703
_displayNameWDR5 and DPY30 interact with the RBBP5:ASH2L heterodimer and...
_timestamp2023-02-10 15:21:03
created[InstanceEdit:9675717] Orlic-Milacic, Marija, 2020-02-04
literatureReference[LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
[LiteratureReference:9675715] WRAD: enabler of the SET1-family of H3K4 methyltransferases
[LiteratureReference:9675716] Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation
[LiteratureReference:9675721] A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex
modified[InstanceEdit:9675722] Orlic-Milacic, Marija, 2020-02-04
[InstanceEdit:9821611] Orlic-Milacic, Marija, 2022-12-09
[InstanceEdit:9821876] Orlic-Milacic, Marija, 2022-12-13
[InstanceEdit:9823550] Orlic-Milacic, Marija, 2023-01-06
[InstanceEdit:9828080] Orlic-Milacic, Marija, 2023-02-10
textWDR5 and DPY30 interact with the RBBP5:ASH2L heterodimer and together form the WRAD complex, which functions as a core subcomplex of all mammalian KMT2 histone methyltransferase complexes (Cho et al. 2007, Patel et al. 2011, Shinsky et al. 2015, reviewed by Ernst and Vakoc 2012). WDR5 directly interacts with RBBP5 (Odho et al. 2010), while DPY30 directly binds to ASH2L (Cho et al. 2007). RBBP5, ASH2L, and DPY30 may form a subcomplex prior to WDR5 binding (van Nuland et al. 2013). Based on stoichiometric analysis, DPY30 likely exists as a homo-oligomer in the WRAD complex (van Nuland et al. 2013).
(summation)[Reaction:9675214] Formation of the WRAD complex [Homo sapiens]
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