Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q10N20-2 MPK5
| Class:Id | ReferenceIsoform:9675686 |
|---|---|
| _chainChangeLog | chain:1-369 for 9675686 added on Sun February 16 2020 |
| _displayName | UniProt:Q10N20-2 MPK5 |
| _timestamp | 2025-02-21 19:40:17 |
| chain | chain:1-369 |
| checksum | 417D81732635F2D3 |
| comment | FUNCTION Involved in disease resistance and abiotic stress tolerance signaling pathways. Acts as a positive regulator of drought, salt and cold tolerance. Negatively modulates pathogenesis-related (PR) gene expression and broad-spectrum disease resistance (PubMed:12615946). Functions downstream of CPK18 in a signaling pathway that represses defense gene expression and negatively regulates resistance to rice blast fungus. Phosphorylated by CPK18 at Thr-14 and Thr-32 and activated independently of MAP kinase kinase (MKK) phosphorylation (PubMed:25035404).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by threonine and tyrosine phosphorylation (By similarity). Activated in response to low temperature (12 degrees Celsius) treatment (PubMed:12177502, PubMed:12615946). Activated by phosphorylation at Thr-14 and Thr-32 by CPK18 (PubMed:25035404).SUBUNIT Interacts with MKK1 (PubMed:12177502). Interacts with CPK18 (PubMed:25035404).SUBCELLULAR LOCATION Expressed in roots, stems and panicles, and at lower levels in leaves.INDUCTION By benzothiadiazole (BTH), dichloroisonicotinic acid, probenazole, jasmonic acid, wounding and infection with P.syringae and M.grisea, by stresses, hormones, heavy metals, high/low temperature, UV-C and phosphatase inhibitors.DOMAIN The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM Dually phosphorylated at Thr-194 and Tyr-196, which activates the enzyme (By similarity). Autophosphorylated. Phosphorylated by CPK18 at Thr-14 and Thr-32, which activates the enzyme (PubMed:25035404).MISCELLANEOUS Does not possess kinase activity.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:9675682] Gupta, Parul, 2020-02-04 |
| description | recommendedName: Mitogen-activated protein kinase 5 shortName: MAP kinase 5 ecNumber: 2.7.11.24 alternativeName: Benzothiadiazole-induced MAP kinase 1 alternativeName: MAP kinase 2 alternativeName: Multiple stress-responsive MAP kinase 2 alternativeName: OsBIMK1 alternativeName: OsMAP1 alternativeName: OsMAPK2 alternativeName: OsMAPK5 alternativeName: OsMPK3 alternativeName: OsMSRMK2 |
| geneName | MPK5 BIMK1 MAPK2 MAPK5 MPK3 MSRMK2 Os03g0285800 LOC_Os03g17700 OsJ_10412 OSJNBa0013D02.9 |
| identifier | Q10N20 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Plant defense Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MPK5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MPK5_ORYSJ B7EDC7 Q7FNE2 Q8GZZ3 Q8S3T6 Q9AXF2 Q9FQM3 Q9FSE6 |
| sequenceLength | 369 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| variantIdentifier | Q10N20-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q10N20-2 MPK5 (9675686)
