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Details on Person Formation of the RBBP5:ASH2L heterodimer

Class:Id	Reaction:9675215
_displayName	Formation of the RBBP5:ASH2L heterodimer
_doRelease	TRUE
_timestamp	2023-02-13 14:50:57
authored	[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9675217] Orlic-Milacic, Marija, 2020-02-03
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
input	[EntityWithAccessionedSequence:1629834] ASH2L [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1629836] RBBP5 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9675242] An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain [LiteratureReference:9675244] Structural basis for activity regulation of MLL family methyltransferases [LiteratureReference:9771858] The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites [LiteratureReference:9772468] A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation [LiteratureReference:9772925] Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes
modified	[InstanceEdit:9675246] Orlic-Milacic, Marija, 2020-02-03 [InstanceEdit:9771883] Orlic-Milacic, Marija, 2022-04-20 [InstanceEdit:9772484] Orlic-Milacic, Marija, 2022-04-22 [InstanceEdit:9772926] Orlic-Milacic, Marija, 2022-04-24 [InstanceEdit:9827914] Orlic-Milacic, Marija, 2023-02-08 [InstanceEdit:9828078] Orlic-Milacic, Marija, 2023-02-10 [InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13 [InstanceEdit:9828331] Orlic-Milacic, Marija, 2023-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the RBBP5:ASH2L heterodimer
output	[Complex:9675216] RBBP5:ASH2L [nucleoplasm] [Homo sapiens]
releaseDate	2023-03-29
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9675221] R-HSA-9675215.2
summation	[Summation:9675233] RBBP5 and ASH2L interact and form a heterodimer (Cao et al. ...
(hasEvent)	[Pathway:9772755] Formation of WDR5-containing histone-modifying complexes [Homo sapiens]
(precedingEvent)	[Reaction:9675214] Formation of the WRAD complex [Homo sapiens]
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No pathways have been reviewed or authored by Formation of the RBBP5:ASH2L heterodimer (9675215)