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Details on Person Transcription of HOXA2 and HOXA10 genes decreases in the pre...
| Class:Id | Summation:9675120 |
|---|---|
| _displayName | Transcription of HOXA2 and HOXA10 genes decreases in the pre... |
| _timestamp | 2020-01-31 17:58:19 |
| created | [InstanceEdit:9675122] Orlic-Milacic, Marija, 2020-01-31 |
| text | Transcription of HOXA2 and HOXA10 genes decreases in the presence of PRMT6, which was shown to directly bind to the HOXA2 promoter region and create an asymmetric dimethylarginine mark on histone H3 (H3R2Me2). Transcriptional activation of HOXA2 coincides with MLL1-mediated methylation of lysine residue K5 (H3K4Me1 mark), which presumably allows loading of MYC, as HOXA2 and HOXA10 are MYC target genes, and MYC loading depends on the H3K4Me1 mark (Hyllus et al. 2007). |
| (summation) | [BlackBoxEvent:9675027] Expression of target genes is stimulated by MYC and WDR5 and inhibited by PRMT6 [Homo sapiens] |
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No pathways have been reviewed or authored by Transcription of HOXA2 and HOXA10 genes decreases in the pre... (9675120)
