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Details on Person PRMT6 methylates R2me1 of histone H3 at target gene promoters

Class:IdReaction:9675030
_displayNamePRMT6 methylates R2me1 of histone H3 at target gene promoters
_timestamp2022-04-24 16:12:45
catalystActivity[CatalystActivity:9675039] histone methyltransferase activity of HOXA2,(HOXA10) gene:H3R2Me1-nucleosome:PRMT6 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9675024] Orlic-Milacic, Marija, 2020-01-29
input[Complex:9675043] HOXA2,(HOXA10) gene:H3R2Me1-nucleosome:PRMT6 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5205806] PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation
[LiteratureReference:5205809] Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
modified[InstanceEdit:9675053] Orlic-Milacic, Marija, 2020-01-29
[InstanceEdit:9675123] Orlic-Milacic, Marija, 2020-01-31
[InstanceEdit:9676291] Orlic-Milacic, Marija, 2020-02-11
[InstanceEdit:9677009] Orlic-Milacic, Marija, 2020-02-25
[InstanceEdit:9772926] Orlic-Milacic, Marija, 2022-04-24
namePRMT6 methylates R2me1 of histone H3 at target gene promoters
output[Complex:9675045] HOXA2,(HOXA10) gene:H3R2Me2-nucleosome:PRMT6 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9675032] R-HSA-9675030.1
summation[Summation:9675025] PRMT6 preferentially methylates monomethylated arginine R2 (...
(hasEvent)[Pathway:9677820] MLLs regulate transcription of homeobox genes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9677039] HOXA2,(HOXA10) gene expression is positively regulated by MLL1 and negatively regulated by PRMT6 [Homo sapiens]
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