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Details on Person MLL1 complex methylates lysine K4 of histone H3 on target gene promoters

Class:IdReaction:9675029
_displayNameMLL1 complex methylates lysine K4 of histone H3 on target gene promoters
_doReleaseFALSE
_timestamp2020-03-10 13:50:37
catalystActivity[CatalystActivity:9677011] histone H3K4 methyltransferase activity of HOXA2,(HOXA10) gene:nucleosome:MLL1 complex [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9675024] Orlic-Milacic, Marija, 2020-01-29
input[Complex:9675046] HOXA2,(HOXA10) gene:nucleosome:MLL1 complex [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5205806] PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation
modified[InstanceEdit:9675053] Orlic-Milacic, Marija, 2020-01-29
[InstanceEdit:9677018] Orlic-Milacic, Marija, 2020-02-25
[InstanceEdit:9677677] Orlic-Milacic, Marija, 2020-03-10
nameMLL1 complex methylates lysine K4 of histone H3 on target gene promoters
output[Complex:9677013] HOXA2 gene,(HOXA10 gene):H3K4Me3-Nucleosome:MLL1 complex [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9675031] R-HSA-9675029.1
summation[Summation:9677674] The MLL1 complex trimethylates histone H3 on lysine residue ...
(hasEvent)[Pathway:9677820] MLLs regulate transcription of homeobox genes [Homo sapiens]
(precedingEvent)[Reaction:9674855] MYC binds WDR5 at target gene promoters [Homo sapiens]
[BlackBoxEvent:9677039] HOXA2,(HOXA10) gene expression is positively regulated by MLL1 and negatively regulated by PRMT6 [Homo sapiens]
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