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Details on Person WDR5 binds the N-tail of histone H3 at target gene promoters

Class:IdReaction:9675028
_displayNameWDR5 binds the N-tail of histone H3 at target gene promoters
_doReleaseFALSE
_timestamp2020-02-25 18:11:28
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9675024] Orlic-Milacic, Marija, 2020-01-29
input[Complex:9675044] HOXA2,(HOXA10) gene:nucleosome [nucleoplasm] [Homo sapiens]
[Complex:9675218] MLL1 complex [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5205806] PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation
modified[InstanceEdit:9675053] Orlic-Milacic, Marija, 2020-01-29
[InstanceEdit:9676291] Orlic-Milacic, Marija, 2020-02-11
[InstanceEdit:9677009] Orlic-Milacic, Marija, 2020-02-25
nameWDR5 binds the N-tail of histone H3 at target gene promoters
output[Complex:9675046] HOXA2,(HOXA10) gene:nucleosome:MLL1 complex [nucleoplasm] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9675033] R-HSA-9675028.1
summation[Summation:9677007] WDR5, as part of the MLL1 complex, binds the N tail of histo...
(hasEvent)[Pathway:9677820] MLLs regulate transcription of homeobox genes [Homo sapiens]
(precedingEvent)[Reaction:9675029] MLL1 complex methylates lysine K4 of histone H3 on target gene promoters [Homo sapiens]
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