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Details on Person Grb2, Shc, and Ptpn11 bind the cytosolic domain of Csf3r (Gc...

Class:IdSummation:9674972
_displayNameGrb2, Shc, and Ptpn11 bind the cytosolic domain of Csf3r (Gc...
_timestamp2020-06-07 10:01:44
created[InstanceEdit:9674890] May, Bruce, 2020-01-29
modified[InstanceEdit:9677574] May, Bruce, 2020-03-07
[InstanceEdit:9678256] May, Bruce, 2020-03-14
[InstanceEdit:9690953] May, Bruce, 2020-06-07
textGrb2, Shc, and Ptpn11 bind the cytosolic domain of Csf3r (Gcsfr) (Barge et al. 1996, de Koning et al. 1996, de Koning et al. 1998, Ward et al. 1998, Kendrick et al. 2004) and are phosphorylated (Barge et al. 1996, de Koning et al. 1996, de Koning et al. 1998, Wang et al. 2008, Jack et al. 2009, Zhang et al. 2011). Ptpn11 (SHP2) directly binds the phosphorylated cytosolic domain of Csf3r (Ward et al. 1998)and also appears to bind Csf3r indirectly via phosphorylated Gab2 (Wang et al. 2008, Futami et al. 2011). Lyn is required for phosphorylation of Gab2 (Zhu et al. 2004). The order of binding and phosphorylation is unknown.
(summation)[BlackBoxEvent:9674973] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11 [Mus musculus]
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