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Details on Person MYC binds WDR5 at target gene promoters

Class:Id	Reaction:9674855
_displayName	MYC binds WDR5 at target gene promoters
_doRelease	FALSE
_timestamp	2022-04-22 13:40:38
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9674856] Orlic-Milacic, Marija, 2020-01-28
input	[Complex:9675041] HOXA2,(HOXA10) gene:H3K4M3-nucleosome:MLL1 complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9770998] Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC [LiteratureReference:9772169] In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer [LiteratureReference:9772500] The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification
modified	[InstanceEdit:9675036] Orlic-Milacic, Marija, 2020-01-29 [InstanceEdit:9675053] Orlic-Milacic, Marija, 2020-01-29 [InstanceEdit:9770996] Orlic-Milacic, Marija, 2022-04-18 [InstanceEdit:9771032] Orlic-Milacic, Marija, 2022-04-18 [InstanceEdit:9772174] Orlic-Milacic, Marija, 2022-04-20 [InstanceEdit:9772504] Orlic-Milacic, Marija, 2022-04-22
name	MYC binds WDR5 at target gene promoters
output	[Complex:9675040] HOXA2,(HOXA10) gene:H3K4Me1-nucleosome:MLL1 complex:MYC:MAX [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9675029] MLL1 complex methylates lysine K4 of histone H3 on target gene promoters [Homo sapiens] [Reaction:9675028] WDR5 binds the N-tail of histone H3 at target gene promoters [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9674858] R-HSA-9674855.1
summation	[Summation:9770995] "MYC binds directly to WDR5 via an invariant sequence motif ...
(hasEvent)	[Pathway:9674854] Transcriptional regulation by WDR5 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9675027] Expression of target genes is stimulated by MYC and WDR5 and inhibited by PRMT6 [Homo sapiens]
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No pathways have been reviewed or authored by MYC binds WDR5 at target gene promoters (9674855)