Query author contributions in Reactome

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Details on Person p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS

Class:Id	Reaction:9674816
_displayName	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
_doRelease	TRUE
_timestamp	2021-08-18 04:28:27
authored	[InstanceEdit:9674604] May, Bruce, 2020-01-15
catalystActivity	[CatalystActivity:9674825] protein tyrosine phosphatase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9674813] protein tyrosine phosphatase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2:SHC1:GRB2:p-Y546,Y584-PTPN11 [plasma membrane] Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674827] May, Bruce, 2020-01-27
edited	[InstanceEdit:9674604] May, Bruce, 2020-01-15
input	[EntityWithAccessionedSequence:9674821] p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9709973] Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
modified	[InstanceEdit:9676078] May, Bruce, 2020-02-07 [InstanceEdit:9677574] May, Bruce, 2020-03-07 [InstanceEdit:9677884] May, Bruce, 2020-03-12 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9709982] May, Bruce, 2020-12-19 [InstanceEdit:9750249] May, Bruce, 2021-08-11 [InstanceEdit:9751089] May, Bruce, 2021-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
output	[SimpleEntity:29372] Pi [cytosol] [EntityWithAccessionedSequence:9674814] S-Farn-Me-PalmS KRAS [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9674808] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) [Homo sapiens] [BlackBoxEvent:9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9674832] R-HSA-9674816.3
summation	[Summation:9674828] CSF3 (G-CSF) signaling activates ERKs (ERK1, ERK2) via RAS. ...
(hasEvent)	[Pathway:9674555] Signaling by CSF3 (G-CSF) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775607] Update Tracker - [Reaction:9674816] p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS - v78:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (9674816)