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Details on Person p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1

Class:Id	Reaction:9674558
_displayName	p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
_doRelease	TRUE
_timestamp	2020-12-12 08:35:33
authored	[InstanceEdit:9674554] May, Bruce, 2020-01-11
catalystActivity	[CatalystActivity:9674922] protein tyrosine kinase activity of CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674559] May, Bruce, 2020-01-15
edited	[InstanceEdit:9674554] May, Bruce, 2020-01-11
inferredFrom	[Reaction:9674921] p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2 [Mus musculus]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9674580] CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9674549] Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor
modified	[InstanceEdit:9675009] May, Bruce, 2020-01-29 [InstanceEdit:9676077] May, Bruce, 2020-02-07 [InstanceEdit:9677157] May, Bruce, 2020-02-28 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9674572] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9674546] CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 [Homo sapiens] [Reaction:9677585] CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9674595] R-HSA-9674558.2
summation	[Summation:9677132] After JAK1 is phosphorylated and thereby activated in respon...
(hasEvent)	[Pathway:9674555] Signaling by CSF3 (G-CSF) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9676071] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK [Homo sapiens]
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