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Details on Person CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1

Class:Id	BlackBoxEvent:9674546
_displayName	CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
_doRelease	TRUE
_timestamp	2020-12-12 08:29:45
authored	[InstanceEdit:9674554] May, Bruce, 2020-01-11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674559] May, Bruce, 2020-01-15
edited	[InstanceEdit:9674554] May, Bruce, 2020-01-11
inferredFrom	[BlackBoxEvent:9674900] Csf3:Csf3r induces phosphorylation of Jak1 [Mus musculus]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9677578] CSF3 dimer:2xCSF3R:LYN:JAK1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9674549] Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor [LiteratureReference:9674893] Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [LiteratureReference:9674947] The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line [LiteratureReference:9674566] Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
modified	[InstanceEdit:9675009] May, Bruce, 2020-01-29 [InstanceEdit:9676076] May, Bruce, 2020-02-07 [InstanceEdit:9677157] May, Bruce, 2020-02-28 [InstanceEdit:9677590] May, Bruce, 2020-03-09 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1
output	[Complex:9674580] CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9677585] CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 [Homo sapiens] [Reaction:9677579] CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9674594] R-HSA-9674546.2
summation	[Summation:9677133] JAK1 is phosphorylated by an unknown kinase in response to C...
(hasEvent)	[Pathway:9674555] Signaling by CSF3 (G-CSF) [Homo sapiens]
(precedingEvent)	[Reaction:9674558] p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [Homo sapiens]
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No pathways have been reviewed or authored by CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (9674546)