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Query author contributions in Reactome

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Details on Person PDGFRs bind type I TKI

Class:IdReaction:9674093
_displayNamePDGFRs bind type I TKI
_doReleaseTRUE
_timestamp2020-02-27 15:47:27
authored[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9674092] Rothfels, Karen, 2020-01-10
edited[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
input[DefinedSet:9674075] type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
[Complex:389079] PDGF alpha receptor: PDGF dimers [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9674057] Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells
[LiteratureReference:9674032] Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
[LiteratureReference:9674068] The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
[LiteratureReference:9674023] Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo
[LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
[LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
modified[InstanceEdit:9674438] Rothfels, Karen, 2020-01-13
[InstanceEdit:9674452] Rothfels, Karen, 2020-01-13
[InstanceEdit:9676310] Rothfels, Karen, 2020-02-12
[InstanceEdit:9677115] Rothfels, Karen, 2020-02-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePDGFRs bind type I TKI
output[Complex:9674082] PDGFR:type I PDGFR-binding TKIs [plasma membrane] [Homo sapiens]
releaseDate2020-03-17
reviewed[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9674094] R-HSA-9674093.2
summation[Summation:9674088] Wild-type PDGFRA and PDGFRB can be bound and inhibited by c...
(hasEvent)[Pathway:186797] Signaling by PDGF [Homo sapiens]
(normalReaction)[Reaction:9674427] PDGFR mutants bind type I TKIs [Homo sapiens]
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No pathways have been reviewed or authored by PDGFRs bind type I TKI (9674093)
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