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Details on Person The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

Class:IdLiteratureReference:9674068
_displayNameThe FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
_timestamp2020-01-10 04:12:46
author[Person:9674065] Mathias, Trevor J
[Person:9674063] Natarajan, Karthika
[Person:6797618] Shukla, Suneet
[Person:9674069] Doshi, Kshama A
[Person:9674067] Singh, Zeba N
[Person:431680] Ambudkar, Suresh V
[Person:9674066] Baer, Maria R
created[InstanceEdit:9674064] Rothfels, Karen, 2020-01-10
journalInvest New Drugs
pages300-9
pubMedIdentifier25597754
titleThe FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
volume33
year2015
(literatureReference)[BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
[Reaction:9674093] PDGFRs bind type I TKI [Homo sapiens]
[DefinedSet:9695790] type I FLT3-binding TKIs [cytosol]
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