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Details on Person Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB

Class:Id	Reaction:9673760
_displayName	Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB
_doRelease	TRUE
_timestamp	2020-02-27 15:47:17
authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9673762] Rothfels, Karen, 2020-01-08
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9673675] gain_of_function of membrane-tethered PDGFR fusions [plasma membrane]
input	[CandidateSet:9673677] membrane-tethered PDGFR fusions [plasma membrane] [Homo sapiens] [CandidateSet:9673677] membrane-tethered PDGFR fusions [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas [LiteratureReference:9673841] TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins [LiteratureReference:9673576] The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways [LiteratureReference:9673500] Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent [LiteratureReference:9018632] KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia [LiteratureReference:9673557] Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies [LiteratureReference:9673580] The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer
modified	[InstanceEdit:9673887] Rothfels, Karen, 2020-01-09 [InstanceEdit:9676111] Rothfels, Karen, 2020-02-07 [InstanceEdit:9676333] Rothfels, Karen, 2020-02-12 [InstanceEdit:9677115] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB
output	[CandidateSet:9673678] membrane-tethered PDGFR fusion dimers [plasma membrane] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9673764] R-HSA-9673760.2
summation	[Summation:9673853] Transmembrane PDGFR fusion proteins dimerize independent of ...
(hasEvent)	[Pathway:9673768] Signaling by membrane-tethered fusions of PDGFRA or PDGFRB [Homo sapiens]
(precedingEvent)	[Reaction:9673761] Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB [Homo sapiens]
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No pathways have been reviewed or authored by Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (9673760)