Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Like the WT receptor, gain-of-function missense and in-frame...
| Class:Id | Summation:9673753 |
|---|---|
| _displayName | Like the WT receptor, gain-of-function missense and in-frame... |
| _timestamp | 2020-02-08 16:56:44 |
| created | [InstanceEdit:9673754] Rothfels, Karen, 2020-01-08 |
| modified | [InstanceEdit:9674505] Rothfels, Karen, 2020-01-13 [InstanceEdit:9676121] Rothfels, Karen, 2020-02-08 |
| text | Like the WT receptor, gain-of-function missense and in-frame deletion mutants of PDGFRA appear to act through the STAT signaling pathway. Binding and phosphorylation of SRC and subsequently STAT1 and 3 has been demonstrated for the activation loop D842V mutant, the juxtamembrane domain V561D mutant and for a small number of short in-frame deletion mutants in the kinase and juxtamembrane domain region. Specificity for interaction with different STAT family members is likely to vary depending on the PDGFRA mutation (Heinrich et al, 2003; Velghe et al, 2014; reviewed in Klug et al, 2018; Wang et al, 2016; Corless et al, 2011). |
| (summation) | [Reaction:9672176] STAT binds to the mutant PDGFRA receptor [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Like the WT receptor, gain-of-function missense and in-frame... (9673753)
