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Details on Person PDGFRA T674I [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9673603
_displayName	PDGFRA T674I [plasma membrane]
_timestamp	2020-01-08 22:25:29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9673605] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:9673604] COSMIC:COSM3724519 [DatabaseIdentifier:9673606] COSMIC:COSV57267767
disease	[Disease:1500689] cancer [Disease:9672476] hypereosinophilic syndrome [Disease:2327994] penis carcinoma [Disease:9632618] nasopharynx carcinoma [Disease:9630839] acute myeloid leukemia
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9672473] L-threonine 674 replaced with L-isoleucine
literatureReference	[LiteratureReference:9672488] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
name	PDGFRA T674I Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:61602] UniProt:P16234 PDGFRA [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9673607] R-HSA-9673603.1
startCoordinate	24
(hasComponent)	[Complex:9673695] PDGFRA T674I dimer [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:9672125] imatinib-resistant PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9672129] imatinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9673717] sorafenib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674343] crenolanib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [CandidateSet:9674353] quizartinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674354] ponatinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by PDGFRA T674I [plasma membrane] (9673603)