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Details on Person The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders

Class:Id	LiteratureReference:9673583
_displayName	The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
_timestamp	2020-01-08 22:24:45
author	[Person:9669257] Roskoski, Robert
created	[InstanceEdit:9673582] Rothfels, Karen, 2020-01-08
journal	Pharmacol. Res.
pages	65-83
pubMedIdentifier	29408302
title	The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
volume	129
year	2018
(literatureReference)	[BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens] [Reaction:389083] Autophosphorylation of PDGF alpha receptors [Homo sapiens] [Pathway:9671555] Signaling by PDGFR in disease [Homo sapiens] [Reaction:9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor [Homo sapiens] [Reaction:9672168] Ligand-independent dimerization of PDGFR mutants [Homo sapiens] [Reaction:9672170] SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors [Homo sapiens] [Reaction:9672172] PI3-kinase binds to mutant PDGFR receptor [Homo sapiens] [Reaction:9672175] Autophosphorylation of PDGFR mutant dimers [Homo sapiens] [Pathway:9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [Homo sapiens] [Reaction:9674093] PDGFRs bind type I TKI [Homo sapiens] List all 18 refering instances
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