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Details on Person WNT5:FZD7 binds p-DVL

Class:IdReaction:9673296
_displayNameWNT5:FZD7 binds p-DVL
_doReleaseTRUE
_timestamp2020-02-05 09:52:18
authored[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
edited[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
input[CandidateSet:3858479] p-DVL [cytosol] [Homo sapiens]
[Complex:9673287] WNT5:FZD7 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3858398] Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
[LiteratureReference:351094] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
[LiteratureReference:208130] Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
[LiteratureReference:3965300] Gpr125 modulates Dishevelled distribution and planar cell polarity signaling
[LiteratureReference:350958] Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
[LiteratureReference:3965326] Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling
[LiteratureReference:3772336] Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis
[LiteratureReference:3965314] Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway
[LiteratureReference:3965315] Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos
[LiteratureReference:3965331] Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane
[LiteratureReference:3965342] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway
modified[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673793] Murillo, Julieth, 2020-01-09
[InstanceEdit:9675740] Murillo, Julieth, 2020-02-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameWNT5:FZD7 binds p-DVL
output[Complex:9673309] WNT5:FZD7:p-DVL [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9673354] R-HSA-9673296.2
summation[Summation:3965347] The DEP domain of dishevelled proteins (DVL) is required bot...
(hasEvent)[Pathway:9673324] WNT5:FZD7-mediated leishmania damping [Homo sapiens]
(precedingEvent)[Reaction:9673346] Unknown kinase phosphorylates p-DVL [Homo sapiens]
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