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Details on Person ppDVL binds RAC1:GTP

Class:Id	Reaction:9673288
_displayName	ppDVL binds RAC1:GTP
_doRelease	TRUE
_timestamp	2020-02-25 18:24:38
authored	[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22 [InstanceEdit:9673371] Jassal, Bijay, 2020-01-07
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
edited	[InstanceEdit:9673371] Jassal, Bijay, 2020-01-07 [InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
input	[Complex:442641] RAC1:GTP [plasma membrane] [Homo sapiens] [Complex:9673343] WNT5:FZD7:pp-DVL [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:351078] Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation [LiteratureReference:351112] Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 [LiteratureReference:3858403] JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates [LiteratureReference:3858427] Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development [LiteratureReference:3858412] Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons [LiteratureReference:3858398] Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [LiteratureReference:351094] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [LiteratureReference:3965302] Mammalian Rho GTPases: new insights into their functions from in vivo studies [LiteratureReference:3247726] Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
modified	[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07 [InstanceEdit:9673793] Murillo, Julieth, 2020-01-09 [InstanceEdit:9675740] Murillo, Julieth, 2020-02-05 [InstanceEdit:9677019] Murillo, Julieth, 2020-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ppDVL binds RAC1:GTP
output	[Complex:9675729] WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9673346] Unknown kinase phosphorylates p-DVL [Homo sapiens] [Reaction:9673296] WNT5:FZD7 binds p-DVL [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9673361] R-HSA-9673288.2
summation	[Summation:3858441] WNT-dependent activation of dishevelled proteins (DVL) induc...
(hasEvent)	[Pathway:9673324] WNT5:FZD7-mediated leishmania damping [Homo sapiens]
(precedingEvent)	[Reaction:9673284] GTP-bound RAC1 contributes to MAPK8 activation [Homo sapiens] [Reaction:9673794] ppDVL:RAC1:GTP binds NOX1 complex [Homo sapiens]
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No pathways have been reviewed or authored by ppDVL binds RAC1:GTP (9673288)