Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person STAT binds to the mutant PDGFRA receptor

Class:Id	Reaction:9672176
_displayName	STAT binds to the mutant PDGFRA receptor
_doRelease	TRUE
_timestamp	2020-02-27 15:47:50
authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672151] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
input	[DefinedSet:9672040] p-11Y PDGFR mutant receptor dimers [plasma membrane] [Homo sapiens] [DefinedSet:1112559] STAT1, STAT3 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors [LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9673580] The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
modified	[InstanceEdit:9673765] Rothfels, Karen, 2020-01-08 [InstanceEdit:9676111] Rothfels, Karen, 2020-02-07 [InstanceEdit:9676333] Rothfels, Karen, 2020-02-12 [InstanceEdit:9677115] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT binds to the mutant PDGFRA receptor
normalReaction	[Reaction:380782] STAT binds to the active receptor [Homo sapiens]
output	[Complex:9672074] p-11Y PDGFRA mutant receptor dimer:STAT [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9672175] Autophosphorylation of PDGFR mutant dimers [Homo sapiens] [Reaction:9672168] Ligand-independent dimerization of PDGFR mutants [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9672187] R-HSA-9672176.2
summation	[Summation:9673753] Like the WT receptor, gain-of-function missense and in-frame...
(hasEvent)	[Pathway:9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by STAT binds to the mutant PDGFRA receptor (9672176)