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Details on Person Autophosphorylation of PDGFR mutant dimers

Class:IdReaction:9672175
_displayNameAutophosphorylation of PDGFR mutant dimers
_doReleaseTRUE
_timestamp2020-02-27 15:46:48
authored[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity[CatalystActivity:9672169] protein tyrosine kinase activity of PDGFR mutant dimers [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
disease[Disease:1500689] cancer
edited[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus[EntityFunctionalStatus:9672147] gain_of_function of PDGFR mutant dimers [plasma membrane]
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:9672131] PDGFR mutant dimers [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors
[LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib
[LiteratureReference:9673515] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
[LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations
[LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
modified[InstanceEdit:9673765] Rothfels, Karen, 2020-01-08
[InstanceEdit:9676111] Rothfels, Karen, 2020-02-07
[InstanceEdit:9676334] Rothfels, Karen, 2020-02-12
[InstanceEdit:9677115] Rothfels, Karen, 2020-02-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutophosphorylation of PDGFR mutant dimers
normalReaction
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[DefinedSet:9672040] p-11Y PDGFR mutant receptor dimers [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9672179] R-HSA-9672175.2
summation[Summation:9673747] Activating mutations in the kinase, juxtamembrane and transm...
(hasEvent)[Pathway:9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [Homo sapiens]
(precedingEvent)[Reaction:9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor [Homo sapiens]
[Reaction:9672172] PI3-kinase binds to mutant PDGFR receptor [Homo sapiens]
[Reaction:9672176] STAT binds to the mutant PDGFRA receptor [Homo sapiens]
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No pathways have been reviewed or authored by Autophosphorylation of PDGFR mutant dimers (9672175)
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