Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Ligand-independent dimerization of PDGFR mutants

Class:IdReaction:9672168
_displayNameLigand-independent dimerization of PDGFR mutants
_doReleaseTRUE
_timestamp2020-02-27 15:47:11
authored[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
disease[Disease:1500689] cancer
edited[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane]
input[DefinedSet:9672123] PDGFR mutant receptors [plasma membrane] [Homo sapiens]
[DefinedSet:9672123] PDGFR mutant receptors [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors
[LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib
[LiteratureReference:9673515] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
[LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
[LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations
[LiteratureReference:9676100] GEIS guidelines for gastrointestinal sarcomas (GIST)
[LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
modified[InstanceEdit:9673765] Rothfels, Karen, 2020-01-08
[InstanceEdit:9676111] Rothfels, Karen, 2020-02-07
[InstanceEdit:9676333] Rothfels, Karen, 2020-02-12
[InstanceEdit:9677115] Rothfels, Karen, 2020-02-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLigand-independent dimerization of PDGFR mutants
normalReaction
output[DefinedSet:9672131] PDGFR mutant dimers [plasma membrane] [Homo sapiens]
releaseDate2020-03-17
reviewed[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9672189] R-HSA-9672168.2
summation[Summation:9673741] Activating missense and small in-frame deletion mutations in...
(hasEvent)[Pathway:9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [Homo sapiens]
(precedingEvent)[Reaction:9672175] Autophosphorylation of PDGFR mutant dimers [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Ligand-independent dimerization of PDGFR mutants (9672168)
Follow Reactome