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Details on Person PDGFRA D842V [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9671549
_displayName	PDGFRA D842V [plasma membrane]
_timestamp	2019-12-19 18:54:41
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9671534] Rothfels, Karen, 2019-12-19
crossReference	[DatabaseIdentifier:9671550] COSMIC:COSV57264120
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671533] L-aspartic acid 842 replaced with L-valine
name	PDGFRA D842V Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:61602] UniProt:P16234 PDGFRA [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9671568] R-HSA-9671549.1
startCoordinate	24
(diseaseEntity)	[EntityFunctionalStatus:9674406] loss_of_function of PDGFRA D842V [plasma membrane]
(hasCandidate)	[CandidateSet:9674353] quizartinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [CandidateSet:9674356] regorafenib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens]
(hasComponent)	[Complex:9672043] PDGFRA D842V dimer [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9672124] kinase domain mutants of PDGFRA [plasma membrane] [Homo sapiens] [DefinedSet:9672125] imatinib-resistant PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9673718] sorafenib-resistant PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674340] midostaurin-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674343] crenolanib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674344] avapritinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674354] ponatinib-sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674358] ripretinib sensitive PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674370] nilotinib-resistant PDGFR mutants [plasma membrane] [Homo sapiens] [DefinedSet:9674375] regorafenib-resistant PDGFR mutants [plasma membrane] [Homo sapiens] List all 11 refering instances
(input)	[FailedReaction:9674398] D842V PDGFRA doesn't bind sunitinib [Homo sapiens] [FailedReaction:9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib [Homo sapiens]
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No pathways have been reviewed or authored by PDGFRA D842V [plasma membrane] (9671549)