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Details on Person KIT mutants:PI3K catalyze synthesis of PIP3
Class:Id Reaction:9670433 _displayName KIT mutants:PI3K catalyze synthesis of PIP3 _doRelease TRUE _timestamp 2020-05-27 10:43:58 authored [InstanceEdit:9681395] Rothfels, Karen, 2020-04-01 catalystActivity [CatalystActivity:9670406] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT mutant dimers [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region created [InstanceEdit:9670432] Rothfels, Karen, 2019-12-09 disease [Disease:1500689] cancer edited [InstanceEdit:9686618] Rothfels, Karen, 2020-05-04 entityFunctionalStatus [EntityFunctionalStatus:9670395] gain_of_function of PI3K:p-KIT mutant dimers [plasma membrane] input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] isChimeric FALSE literatureReference [LiteratureReference:9669213] KIT mutations are common in testicular seminomas [LiteratureReference:9669177] KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors [LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway [LiteratureReference:9680303] Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs) [LiteratureReference:9680542] Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms [LiteratureReference:9680290] Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor [LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications modified [InstanceEdit:9670527] Rothfels, Karen, 2019-12-09 [InstanceEdit:9679387] Rothfels, Karen, 2020-03-24 [InstanceEdit:9680547] Rothfels, Karen, 2020-03-27 [InstanceEdit:9681434] Rothfels, Karen, 2020-04-01 [InstanceEdit:9686298] Rothfels, Karen, 2020-04-29 [InstanceEdit:9689924] Rothfels, Karen, 2020-05-22 [InstanceEdit:9690167] Rothfels, Karen, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name KIT mutants:PI3K catalyze synthesis of PIP3 normalReaction
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] precedingEvent
releaseDate 2020-06-10 reviewed [InstanceEdit:9678239] Serrano, César, 2020-03-13 [InstanceEdit:9678232] García-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9670435] R-HSA-9670433.2 summation [Summation:9670511] PI3K/AKT signaling is initiated downstream of KIT juxtamembr... (hasEvent) [Pathway:9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants [Homo sapiens]
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