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Details on Person CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP

Class:Id	Reaction:9670155
_displayName	CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP
_doRelease	TRUE
_timestamp	2020-02-24 12:36:30
authored	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
inferredFrom	[Reaction:442572] Activation of WASP and N-WASP by CDC42 [Mus musculus]
input	[Complex:182921] CDC42:GTP [plasma membrane] [Homo sapiens] [Complex:9667225] PI(4,5)P2:WASP/N-WASP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:442552] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [LiteratureReference:2028916] EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family [LiteratureReference:372997] Regulation of WASP/WAVE proteins: making a long story short [LiteratureReference:2028918] Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein [LiteratureReference:2028921] Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP [LiteratureReference:2028917] Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
modified	[InstanceEdit:9673427] Murillo, Julieth, 2020-01-07 [InstanceEdit:9675730] Murillo, Julieth, 2020-02-05 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9676933] Jassal, Bijay, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP
output	[Complex:442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9670156] PtdIns(4,5)P2 binds WASP, N-WASP [Homo sapiens] [BlackBoxEvent:2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9670161] R-HSA-9670155.2
summation	[Summation:442581] Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-W...
(hasEvent)	[Pathway:9664422] FCGR3A-mediated phagocytosis [Homo sapiens]
(precedingEvent)	[Reaction:2197691] WIP binds WASP,N-WASP, activating them [Homo sapiens]
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No pathways have been reviewed or authored by CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (9670155)