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Details on Person Defects in F8 A1 domain accelerate dissociation of the A2 domain

Class:Id	Reaction:9670049
_displayName	Defects in F8 A1 domain accelerate dissociation of the A2 domain
_doRelease	TRUE
_timestamp	2026-01-27 18:36:44
authored	[InstanceEdit:9660568] Shamovsky, Veronica, 2019-09-09
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9670053] Shamovsky, Veronica, 2019-12-04
disease	[Disease:9661959] factor VIII deficiency
edited	[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9670057] gain_of_function of factor VIIIa with defective A1 domain [extracellular region]
input	[Complex:9670038] factor VIIIa with defective A1 domain [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9670042] Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa [LiteratureReference:9670046] Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: evidence for nonproteolytic inactivation of factor VIIIa in vivo
modified	[InstanceEdit:9670167] Shamovsky, Veronica, 2019-12-06 [InstanceEdit:9676086] Shamovsky, Veronica, 2020-02-07 [InstanceEdit:9676352] Shamovsky, Veronica, 2020-02-13 [InstanceEdit:9681504] Shamovsky, Veronica, 2020-04-02 [InstanceEdit:9686299] Shamovsky, Veronica, 2020-04-29 [InstanceEdit:9687144] Shamovsky, Veronica, 2020-05-06 [InstanceEdit:9690135] Shamovsky, Veronica, 2020-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9980375] Shamovsky, Veronica, 2026-01-27
name	Defects in F8 A1 domain accelerate dissociation of the A2 domain
output	[EntityWithAccessionedSequence:158199] F8(392-759) [extracellular region] [Homo sapiens] [Complex:9670061] factor VIIIa A1 variant:A3-C1-C2 [extracellular region] [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09 [InstanceEdit:9681505] Zhang, Bin, 2020-04-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9670069] R-HSA-9670049.3
summation	[Summation:9670034] Factor VIII (FVIII) circulates in plasma as a heterodimer (d...
(hasEvent)	[Pathway:9672387] Defective F8 accelerates dissociation of the A2 domain [Homo sapiens]
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