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Details on Person Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa

Class:Id	LiteratureReference:9670042
_displayName	Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa
_timestamp	2019-12-04 06:48:19
author	[Person:9661584] Pipe, S W [Person:5607022] Saenko, E L [Person:9670050] Eickhorst, A N [Person:9662026] Kemball-Cook, G [Person:9661662] Kaufman, R J
created	[InstanceEdit:9670053] Shamovsky, Veronica, 2019-12-04
journal	Blood
pages	685-91
pubMedIdentifier	11157485
title	Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa
volume	97
year	2001
(literatureReference)	[Reaction:9670049] Defects in F8 A1 domain accelerate dissociation of the A2 domain [Homo sapiens] [Reaction:9670054] Defects in F8 A2 domain accelerate dissociation of the A2 domain [Homo sapiens] [Pathway:9672387] Defective F8 accelerates dissociation of the A2 domain [Homo sapiens] [Summation:9670028] Factor VIII (FVIII) circulates in plasma as a heterodimer (d... [Summation:9670034] Factor VIII (FVIII) circulates in plasma as a heterodimer (d... [CandidateSet:9670027] F8(392-759) A2 domain variant [extracellular region] [Homo sapiens] [DefinedSet:9670040] F8(20-372) variant [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9670041] F8(392-759) R550H [extracellular region] [Homo sapiens]
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