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Details on Person Ligand-independent dimerization of KIT juxtamembrane domain mutants

Class:IdReaction:9669906
_displayNameLigand-independent dimerization of KIT juxtamembrane domain mutants
_doReleaseTRUE
_timestamp2020-05-27 10:45:02
authored[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9669904] Rothfels, Karen, 2019-12-03
disease[Disease:1500689] cancer
edited[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus[EntityFunctionalStatus:9669905] gain_of_function of juxtamembrane domain KIT mutants [plasma membrane]
input[CandidateSet:9669757] juxtamembrane domain KIT mutants [plasma membrane] [Homo sapiens]
[CandidateSet:9669757] juxtamembrane domain KIT mutants [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9669184] KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)
[LiteratureReference:9669259] The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders
[LiteratureReference:9669168] Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region
[LiteratureReference:9669068] Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region
[LiteratureReference:9669247] Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase
[LiteratureReference:9669220] Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
[LiteratureReference:9669106] Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
[LiteratureReference:9669155] Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
[LiteratureReference:1433334] Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
modified[InstanceEdit:9669984] Rothfels, Karen, 2019-12-03
[InstanceEdit:9679387] Rothfels, Karen, 2020-03-24
[InstanceEdit:9680211] Rothfels, Karen, 2020-03-25
[InstanceEdit:9680245] Rothfels, Karen, 2020-03-26
[InstanceEdit:9681434] Rothfels, Karen, 2020-04-01
[InstanceEdit:9686298] Rothfels, Karen, 2020-04-29
[InstanceEdit:9690167] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLigand-independent dimerization of KIT juxtamembrane domain mutants
output[CandidateSet:9669754] juxtamembrane domain KIT mutant dimers [plasma membrane] [Homo sapiens]
releaseDate2020-06-10
reviewed[InstanceEdit:9678239] Serrano, César, 2020-03-13
[InstanceEdit:9678232] García-Valverde, Alfonso, 2020-03-13
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9669907] R-HSA-9669906.2
summation[Summation:9669284] Mutations of exon 11 of KIT are common initiating events in ...
(hasEvent)[Pathway:9669935] Signaling by juxtamembrane domain KIT mutants [Homo sapiens]
(precedingEvent)[Reaction:9669911] Phosphorylation of juxtamembrane domain KIT mutants [Homo sapiens]
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