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Details on Person Constitutive phosphorylation of kinase domain KIT mutants

Class:IdReaction:9669890
_displayNameConstitutive phosphorylation of kinase domain KIT mutants
_doReleaseTRUE
_timestamp2020-05-27 00:25:04
authored[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
catalystActivity[CatalystActivity:9669891] protein tyrosine kinase activity of kinase domain KIT mutants [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9669888] Rothfels, Karen, 2019-12-03
disease[Disease:1500689] cancer
edited[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus[EntityFunctionalStatus:9669889] gain_of_function of kinase domain KIT mutants [plasma membrane]
input[CandidateSet:9669760] kinase domain KIT mutants [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9669155] Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
[LiteratureReference:9669122] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
[LiteratureReference:9669220] Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
[LiteratureReference:9669134] Gastrointestinal stromal tumor (GIST) pathogenesis, familial GIST, and animal models
[LiteratureReference:9669259] The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders
[LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
modified[InstanceEdit:9679387] Rothfels, Karen, 2020-03-24
[InstanceEdit:9680211] Rothfels, Karen, 2020-03-25
[InstanceEdit:9681434] Rothfels, Karen, 2020-04-01
[InstanceEdit:9686297] Rothfels, Karen, 2020-04-29
[InstanceEdit:9690148] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameConstitutive phosphorylation of kinase domain KIT mutants
output[CandidateSet:9669820] p7Y-kinase domain KIT mutants [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
releaseDate2020-06-10
reviewed[InstanceEdit:9678239] Serrano, César, 2020-03-13
[InstanceEdit:9678232] García-Valverde, Alfonso, 2020-03-13
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9669892] R-HSA-9669890.2
summation[Summation:9669273] Activating kinase domain mutants of KIT are constitutively a...
(hasEvent)[Pathway:9669933] Signaling by kinase domain mutants of KIT [Homo sapiens]
(precedingEvent)[Reaction:9670414] KIT mutants bind SFKs [Homo sapiens]
[Reaction:9670428] KIT mutants bind GRB2-SOS [Homo sapiens]
[Reaction:9670431] Phosphorylated KIT mutants bind PI3K [Homo sapiens]
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No pathways have been reviewed or authored by Constitutive phosphorylation of kinase domain KIT mutants (9669890)
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