Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Negative regulation by 'KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]' Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Class:IdRegulationReference:9669883
_displayNameNegative regulation by 'KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]' Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
_timestamp2019-12-03 01:20:42
created[InstanceEdit:9669882] Rothfels, Karen, 2019-12-03
literatureReference[LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
[LiteratureReference:9669059] Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
regulation[NegativeRegulation:9669884] Negative regulation by 'KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]'
(regulationReference)[Reaction:205289] Autophosphorylation of KIT [Homo sapiens]
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No pathways have been reviewed or authored by Negative regulation by 'KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]' Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours (9669883)
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