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Details on Person Dasatinib-resistant KIT mutants do not bind dasatinib
| Class:Id | FailedReaction:9669855 |
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| _displayName | Dasatinib-resistant KIT mutants do not bind dasatinib |
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| _doRelease | TRUE |
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| _timestamp | 2020-05-27 10:38:19 |
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| authored | [InstanceEdit:9681395] Rothfels, Karen, 2020-04-01 |
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| compartment | [Compartment:876] plasma membrane |
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| created | [InstanceEdit:9669852] Rothfels, Karen, 2019-12-03 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9686618] Rothfels, Karen, 2020-05-04 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9669853] loss_of_function of dasatinib resistant KIT mutants [plasma membrane] |
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| input | [DefinedSet:9669732] dasatinib resistant KIT mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9669723] dasatinib [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9671362] Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
[LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours |
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| modified | [InstanceEdit:9671505] Rothfels, Karen, 2019-12-19
[InstanceEdit:9674492] Rothfels, Karen, 2020-01-13
[InstanceEdit:9679387] Rothfels, Karen, 2020-03-24
[InstanceEdit:9680616] Rothfels, Karen, 2020-03-27
[InstanceEdit:9681434] Rothfels, Karen, 2020-04-01
[InstanceEdit:9686298] Rothfels, Karen, 2020-04-29
[InstanceEdit:9690167] Rothfels, Karen, 2020-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Dasatinib-resistant KIT mutants do not bind dasatinib |
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| normalReaction |
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| releaseDate | 2020-06-10 |
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| reviewed | [InstanceEdit:9678239] Serrano, César, 2020-03-13
[InstanceEdit:9678232] García-Valverde, Alfonso, 2020-03-13
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9669857] R-HSA-9669855.2 |
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| summation | [Summation:9671468] KIT receptors bearing mutations in the ATP-binding pocket ar... |
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| (hasEvent) | [Pathway:9669914] Dasatinib-resistant KIT mutants [Homo sapiens] |
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No pathways have been reviewed or authored by Dasatinib-resistant KIT mutants do not bind dasatinib (9669855)
