Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person p-7Y-KIT K550I;P551_V555del [plasma membrane]

Class:IdEntityWithAccessionedSequence:9669602
_displayNamep-7Y-KIT K550I;P551_V555del [plasma membrane]
_timestamp2023-04-01 01:40:06
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9669599] Rothfels, Karen, 2019-12-03
disease[Disease:9661830] gastrointestinal stromal tumor
[Disease:1500689] cancer
endCoordinate976
hasModifiedResidue[ReplacedResidue:9669442] L-lysine 550 replaced with L-isoleucine
[FragmentDeletionModification:9669439] Deletion of residues 551 to 555
[ModifiedResidue:205176] O4'-phospho-L-tyrosine at 568
[ModifiedResidue:205169] O4'-phospho-L-tyrosine at 570
[ModifiedResidue:205278] O4'-phospho-L-tyrosine at 703
[ModifiedResidue:205171] O4'-phospho-L-tyrosine at 721
[ModifiedResidue:205288] O4'-phospho-L-tyrosine at 730
[ModifiedResidue:205235] O4'-phospho-L-tyrosine at 823
[ModifiedResidue:205246] O4'-phospho-L-tyrosine at 936
literatureReference[LiteratureReference:9669122] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
modified[InstanceEdit:9832451] Orlic-Milacic, Marija, 2023-04-01
namep-7Y-KIT K550I;P551_V555del
Mast/stem cell growth factor receptor precursor
KIT_HUMAN
c-KIT
referenceEntity[ReferenceGeneProduct:58103] UniProt:P10721 KIT [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9669642] R-HSA-9669602.2
startCoordinate26
(hasComponent)[Complex:9669775] p7Y-KIT K550I P551_V555del dimer [plasma membrane] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9905365] Update Tracker - [EntityWithAccessionedSequence:9669602] p-7Y-KIT K550I;P551_V555del [plasma membrane] - v85:[modifyName]
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No pathways have been reviewed or authored by p-7Y-KIT K550I;P551_V555del [plasma membrane] (9669602)