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Details on Person The DNA2 endonuclease removes the initiator RNA along with s...

Class:IdSummation:9669149
_displayNameThe DNA2 endonuclease removes the initiator RNA along with s...
_timestamp2020-05-04 19:23:21
created[InstanceEdit:9669150] Orlic-Milacic, Marija, 2019-12-02
literatureReference[LiteratureReference:69146] The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo.
[LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes.
[LiteratureReference:9686644] Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication
[LiteratureReference:9686641] Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
modified[InstanceEdit:9686646] Orlic-Milacic, Marija, 2020-05-04
textThe DNA2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and DNA2. The current data for the role of the DNA2 endonuclease has been derived from studies of yeast (Budd et al. 2000, Bae et al. 2001) and Xenopus DNA2 (Liu et al. 2000, Liao et al. 2008). DNA2-mediated cleavage of G-quadruplexes (G4), DNA structures commonly formed by polyguanine-rich telomeric DNA sequences, is necessary for completion of telomeric DNA synthesis (Masuda-Sasa et al. 2008, Lin et al. 2013).
(summation)[Reaction:174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand [Homo sapiens]
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