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Details on Person The first step in the removal of the flap intermediate is th...
| Class:Id | Summation:9668995 |
|---|---|
| _displayName | The first step in the removal of the flap intermediate is th... |
| _timestamp | 2020-05-04 19:17:33 |
| created | [InstanceEdit:9668994] Orlic-Milacic, Marija, 2019-12-02 |
| literatureReference | [LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes. [LiteratureReference:9668993] Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition |
| modified | [InstanceEdit:9669007] Orlic-Milacic, Marija, 2019-12-02 [InstanceEdit:9686638] Orlic-Milacic, Marija, 2020-05-04 |
| text | The first step in the removal of the flap intermediate is the binding of Replication Protein A (RPA) to the long flap structure. RPA is a eukaryotic single-stranded DNA binding protein (Bae et al. 2001). Binding of RPA to the single strand DNA during telomeric strand displacement synthesis is necessary for the recruitment of DNA2. DNA2 is a helicase/endonuclease that resolves G quadruplexes (G4), which are DNA structures that commonly form in polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008). DNA2 also removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001). |
| (summation) | [Reaction:174445] RPA binds to the Flap on the C-strand [Homo sapiens] |
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No pathways have been reviewed or authored by The first step in the removal of the flap intermediate is th... (9668995)
