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Details on Person After RPA binds the long flap, it recruits the DNA2 helicase...

Class:IdSummation:9668992
_displayNameAfter RPA binds the long flap, it recruits the DNA2 helicase...
_timestamp2019-12-02 20:55:14
created[InstanceEdit:9668994] Orlic-Milacic, Marija, 2019-12-02
literatureReference[LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes.
[LiteratureReference:9668993] Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition
[LiteratureReference:9669004] Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
modified[InstanceEdit:9669007] Orlic-Milacic, Marija, 2019-12-02
[InstanceEdit:9669158] Orlic-Milacic, Marija, 2019-12-02
textAfter RPA binds the long flap, it recruits the DNA2 helicase/endonuclease which removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001). DNA2 is also needed to resolve G quadruplexes (G4), DNA structures commonly formed by polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008, Lin et al. 2013).
(summation)[Reaction:174451] Recruitment of DNA2 endonuclease to the C strand [Homo sapiens]
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