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Details on Person Hyperactivation of factor X by FVIIIa:FIXa R384L

Class:Id	Reaction:9668253
_displayName	Hyperactivation of factor X by FVIIIa:FIXa R384L
_doRelease	TRUE
_timestamp	2020-05-26 22:04:11
authored	[InstanceEdit:9660568] Shamovsky, Veronica, 2019-09-09
catalystActivity	[CatalystActivity:9668248] serine-type endopeptidase activity of FVIIIa:FIXa R384L [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9668265] serine-type endopeptidase activity of FVIIIa:FIXa R384L [plasma membrane] X-linked thrombophilia with a mutant factor IX (factor IX Padua)
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9668266] Shamovsky, Veronica, 2019-11-22
disease	[Disease:9668251] thrombophilia
edited	[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9668252] gain_of_function of FVIIIa:FIXa R384L [plasma membrane]
input	[Complex:140739] factor X [extracellular region] [Homo sapiens] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region]
literatureReference	[LiteratureReference:9668256] X-linked thrombophilia with a mutant factor IX (factor IX Padua)
modified	[InstanceEdit:9676086] Shamovsky, Veronica, 2020-02-07 [InstanceEdit:9676354] Shamovsky, Veronica, 2020-02-13 [InstanceEdit:9681504] Shamovsky, Veronica, 2020-04-02 [InstanceEdit:9686299] Shamovsky, Veronica, 2020-04-29 [InstanceEdit:9687144] Shamovsky, Veronica, 2020-05-06 [InstanceEdit:9690135] Shamovsky, Veronica, 2020-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hyperactivation of factor X by FVIIIa:FIXa R384L Defective factor IX causes thrombophilia
normalReaction	[Reaction:158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) [Homo sapiens]
output	[Complex:140689] factor Xa [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140785] factor X activation peptide [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa [Homo sapiens] [Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer [Homo sapiens] [Reaction:158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) [Homo sapiens] [Reaction:9929054] TF:FVIIa:FIXa ->TF:FVIIa + FIXa [Homo sapiens] [Reaction:140823] OBSOLETE_factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)_REPLACEMENT_9929051_9929054 [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09 [InstanceEdit:9681505] Zhang, Bin, 2020-04-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9668270] R-HSA-9668253.2
summation	[Summation:9668259] In healthy individuals factor IXa (FIXa), in a complex with ...
(hasEvent)	[Pathway:9672383] Defective factor IX causes thrombophilia [Homo sapiens]
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No pathways have been reviewed or authored by Hyperactivation of factor X by FVIIIa:FIXa R384L (9668253)