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Details on Person Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1

Class:IdReaction:9665706
_displayNamePhosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
_doReleaseTRUE
_timestamp2020-02-13 21:17:26
authored[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus[EntityFunctionalStatus:9665923] gain_of_function of p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane]
input[Complex:9665925] p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:202320] PLCG1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
modified[InstanceEdit:9665729] Orlic-Milacic, Marija, 2019-10-31
[InstanceEdit:9665748] Orlic-Milacic, Marija, 2019-10-31
[InstanceEdit:9665931] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666031] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePhosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
normalReaction
output[Complex:9665924] p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2020-03-17
reviewed[InstanceEdit:9666036] Bose, Ron, 2019-10-25
[InstanceEdit:9666034] Krishna, Anagha, 2019-10-25
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9665724] R-HSA-9665706.2
summation[Summation:9665744] Activation of downstream PLCG1 signaling was demonstrated fo...
(hasEvent)[Pathway:9665686] Signaling by ERBB2 TMD/JMD mutants [Homo sapiens]
(precedingEvent)[Reaction:9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 [Homo sapiens]
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