Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1

Class:Id	Reaction:9665698
_displayName	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1
_doRelease	TRUE
_timestamp	2020-02-13 21:17:23
authored	[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665918] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR [plasma membrane]
input	[Complex:9665917] p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
modified	[InstanceEdit:9665729] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665748] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665922] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666031] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1
normalReaction	[Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens]
output	[Complex:9665916] p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate [Homo sapiens] [Reaction:9665697] ERBB2 TMD/JMD mutants hetrodimerize [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9665714] R-HSA-9665698.2
summation	[Summation:9665732] Activation of downstream RAS signaling was shown for ERBB2 S...
(hasEvent)	[Pathway:9665686] Signaling by ERBB2 TMD/JMD mutants [Homo sapiens]
(precedingEvent)	[Reaction:9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (9665698)