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Details on Person ERBB2 TMD/JMD mutants hetrodimerize

Class:Id	Reaction:9665697
_displayName	ERBB2 TMD/JMD mutants hetrodimerize
_doRelease	TRUE
_timestamp	2020-02-13 21:16:53
authored	[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665889] gain_of_function of ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
input	[Complex:9665870] ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [CandidateSet:9646489] Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib [LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
modified	[InstanceEdit:9665729] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665748] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665907] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666031] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666694] Orlic-Milacic, Marija, 2019-11-05 [InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 TMD/JMD mutants hetrodimerize
normalReaction	[Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens]
output	[Complex:9665867] ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9665711] R-HSA-9665697.2
summation	[Summation:9665746] TMD/JMD mutants that are activating in the presence of wild ...
(hasEvent)	[Pathway:9665686] Signaling by ERBB2 TMD/JMD mutants [Homo sapiens]
(precedingEvent)	[Reaction:9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 TMD/JMD mutants hetrodimerize (9665697)