Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Pexophagy

Class:IdPathwayDiagram:9665500
_displayNameDiagram of Pexophagy
_timestamp2022-02-14 17:55:47
created[InstanceEdit:9665501] Varusai, Thawfeek, 2019-10-31
height1241
modified[InstanceEdit:9674153] Varusai, Thawfeek, 2020-01-10
[InstanceEdit:9765010] May, Bruce, 2022-02-14
representedPathway[Pathway:9664873] Pexophagy [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="169" reactomeDiagramId="9665500"> <Properties> <displayName>Diagram of Pexophagy</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="1" reactomeId="70101" position="1004 636" bounds="51 39 1906 1194" textPosition="64 1181" bgColor="250 240 240" lineColor="255 153 102" insets="60 47 1886 1175"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="13" /> <Component id="14" /> <Component id="15" /> <Component id="16" /> <Component id="17" /> <Component id="38" /> <Component id="42" /> <Component id="66" /> <Component id="78" /> <Component id="110" /> <Component id="111" /> <Component id="113" /> <Component id="162" /> <Component id="161" /> <Component id="160" /> <Component id="165" /> <Component id="167" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="14" reactomeId="9033132" position="295 257" bounds="247 246 96 22" textPosition="276 246"> <Properties> <displayName>PEX5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15" reactomeId="9665171" position="295 185" bounds="249 174 92 22" textPosition="278 174"> <Properties> <displayName>ATM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="16" reactomeId="9665170" position="516 223" bounds="453 212 126 22" textPosition="482 213" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="18" reactomeId="9665176" position="516 353" bounds="464 327 105 53" textPosition="482 359" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM:PEX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="38" reactomeId="17951" position="1032 640" bounds="385 347 1295 586" textPosition="902 374" bgColor="250 240 240" lineColor="255 153 102" insets="395 357 1272 564"> <Properties> <displayName>peroxisomal matrix</displayName> </Properties> <Components> <Component id="18" /> <Component id="39" /> <Component id="40" /> <Component id="41" /> <Component id="112" /> <Component id="132" /> <Component id="133" /> <Component id="135" /> <Component id="137" /> <Component id="134" /> <Component id="136" /> <Component id="53" /> <Component id="52" /> <Component id="139" /> <Component id="67" /> <Component id="54" /> <Component id="140" /> <Component id="141" /> <Component id="77" /> <Component id="65" /> <Component id="79" /> <Component id="55" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="40" reactomeId="9665169" position="520 445" bounds="459 427 122 36" textPosition="503 434" /> <org.gk.render.RenderableComplex id="41" reactomeId="9665185" position="776 351" bounds="721 326 111 50" textPosition="723 355" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:PEX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="42" reactomeId="1250243" position="646 274" bounds="598 259 96 30" textPosition="630 263"> <Properties> <displayName>ROS</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="53" reactomeId="9665178" position="1012 344" bounds="947 326 130 37" textPosition="951 342" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:p-PEX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="55" reactomeId="9665179" position="1689 353" bounds="1607 338 165 31" textPosition="1617 348" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="66" reactomeId="193937" position="1751 517" bounds="1691 505 120 24" textPosition="1723 506"> <Properties> <displayName>SQSTM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="67" reactomeId="9665168" position="1674 702" bounds="1597 676 154 52" textPosition="1600 693" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5:SQSTM1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="78" reactomeId="5205651" position="1771 751" bounds="1706 740 130 22" textPosition="1736 740"> <Properties> <displayName>MAP1LC3B</displayName> </Properties> <Shortcuts> <Shortcut id="78" /> <Shortcut id="165" /> <Shortcut id="167" /> </Shortcuts> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="79" reactomeId="9665167" position="1674 915" bounds="1598 875 153 81" textPosition="1600 921" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="111" reactomeId="9665180" position="173 702" bounds="125 691 96 22" textPosition="153 691"> <Properties> <displayName>NBR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="112" reactomeId="9665177" position="388 702" bounds="321 683 135 38" textPosition="368 691" /> <org.gk.render.RenderableProtein id="113" reactomeId="1234119" position="268 657" bounds="214 645 109 25" textPosition="246 647"> <Properties> <displayName>EPAS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="133" reactomeId="9665173" position="396 533" bounds="339 504 115 58" textPosition="343 541" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NBR1:MAP1LC3B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="135" reactomeId="9665165" position="410 908" bounds="339 874 142 69" textPosition="347 908" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5:SQSTM1:NBR1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="137" reactomeId="9665166" position="1432 916" bounds="1355 884 154 65" textPosition="1358 900" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="140" reactomeId="9674135" position="1542 349" bounds="1519 338 46 22" textPosition="1519 338"> <Properties> <displayName>USP30</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="141" reactomeId="9674136" position="1396 351" bounds="1340 333 112 36" textPosition="1346 334" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATM dimer:Ub-p-PEX5:USP30</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="161" reactomeId="29356" position="1416 217" bounds="1388 200 57 35" textPosition="1399 207"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="162" reactomeId="113595" position="1160 318" bounds="1140 305 40 26" textPosition="1148 307"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="165" reactomeId="5205651" position="732 975" bounds="667 964 130 22" textPosition="697 964" /> <org.gk.render.RenderableProtein id="167" reactomeId="5205651" position="274 617" bounds="209 606 130 22" textPosition="239 606" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="13" reactomeId="9664850" points="359 219, 405 219, 450 220" position="405 219" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="313 243" /> <Input id="15" points="315 199" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>ATM binds PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="9664883" points="516 237, 516 284, 516 324" position="516 284" lineWidth="1.0"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Properties> <displayName>ATM:PEX5 translocates from cytosol to peroxisomal membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="39" reactomeId="9664879" points="598 404, 635 404, 658 352, 718 351" position="658 352" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" points="558 383" /> <Input id="40" points="554 424" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Activators> <Activator id="42" points="648 292" /> </Activators> <Properties> <displayName>ATM:PEX5 binds ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="9664862" points="835 351, 887 351, 944 347" position="887 351" lineWidth="1.0"> <Inputs> <Input id="41" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Properties> <displayName>ATM dimer:PEX5 phosphorylates PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="9664888" points="1203 476, 1617 472, 1679 372" position="1617 472" lineWidth="1.0"> <Inputs> <Input id="53" points="1038 366" /> <Input id="162" points="1163 337" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> <Properties> <displayName>ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="9664892" points="1676 583, 1674 628, 1674 673" position="1674 628" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="55" points="1688 372" /> <Input id="66" points="1737 532" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Properties> <displayName>SQSTM1 binds ATM dimer:Ub-p-PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="9664855" points="1693 778, 1673 804, 1673 872" position="1673 804" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="78" points="1739 765" /> <Input id="67" points="1680 731" /> </Inputs> <Outputs> <Output id="79" /> </Outputs> <Properties> <displayName>MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="9664871" points="224 702, 269 702, 318 702" position="269 702" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="111" /> </Inputs> <Outputs> <Output id="112" /> </Outputs> <Activators> <Activator id="113" points="268 673" /> </Activators> <Properties> <displayName>NBR1 translocates from cytosol to perixosomal membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="132" reactomeId="9664867" points="385 623, 397 600, 396 565" position="397 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" points="387 680" /> <Input id="167" points="342 620" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Properties> <displayName>NBR1 binds MAP1LC3B</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="9664881" points="453 774, 410 805, 410 871" position="410 805" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" points="405 724" /> <Input id="67" points="1594 706" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Properties> <displayName>NBR1 binds ATM:Ub-p-PEX5:SQSTM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="9664880" points="1135 894, 1244 893, 1352 906" position="1244 893" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="135" points="484 906" /> <Input id="165" points="786 961" /> </Inputs> <Outputs> <Output id="137" /> </Outputs> <Properties> <displayName>MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="139" reactomeId="9674131" points="1520 448, 1470 449, 1409 372" position="1470 449" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="55" points="1661 372" /> <Input id="140" points="1539 363" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Properties> <displayName>USP30 binds ATM dimer:Ub-p-PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="160" reactomeId="9674127" points="1329 276, 1217 276, 1183 276" position="1217 276" lineWidth="1.0"> <Inputs> <Input id="161" points="1390 238" /> <Input id="141" points="1379 330" /> </Inputs> <Outputs> <Output id="53" points="1058 323" /> <Output id="162" points="1167 299" /> </Outputs> <Catalysts> <Catalyst id="141" points="1337 351, 1218 351" /> </Catalysts> <Properties> <displayName>USP30 deubiquitinates ATM dimer:Ub-p-PEX5</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width1965
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Pexophagy (9665500)
Follow Reactome