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Details on Person gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]

Class:IdEntityFunctionalStatus:9665462
_displayNamegain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
_timestamp2019-10-31 01:55:05
created[InstanceEdit:9665458] Orlic-Milacic, Marija, 2019-10-31
diseaseEntity[Complex:9665460] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens]
functionalStatus[FunctionalStatus:2362351] gain_of_function via non_conservative_missense_variant
normalEntity[Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] [Homo sapiens]
(entityFunctionalStatus)[Reaction:9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 [Homo sapiens]
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No pathways have been reviewed or authored by gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] (9665462)