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Details on Person GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR

Class:Id	Reaction:9665409
_displayName	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
_doRelease	TRUE
_timestamp	2020-02-13 21:16:55
authored	[InstanceEdit:9665122] Orlic-Milacic, Marija, 2019-10-30
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665414] Orlic-Milacic, Marija, 2019-10-30
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665448] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
input	[Complex:9665380] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
modified	[InstanceEdit:9665432] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9665457] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665487] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665496] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
normalReaction	[Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens]
output	[Complex:9665449] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate [Homo sapiens] [Reaction:9665388] ERBB2 ECD mutants heterodimerize with EGFR [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9665422] R-HSA-9665409.2
summation	[Summation:9665486] RAS signaling is activated dowsntream of ERBB2 ECD mutants E...
(hasEvent)	[Pathway:9665348] Signaling by ERBB2 ECD mutants [Homo sapiens]
(precedingEvent)	[Reaction:9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 [Homo sapiens]
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No pathways have been reviewed or authored by GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (9665409)