Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

Class:Id	Reaction:9665408
_displayName	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
_doRelease	TRUE
_timestamp	2020-02-13 21:17:36
authored	[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30
catalystActivity	[CatalystActivity:9665452] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665414] Orlic-Milacic, Marija, 2019-10-30
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665450] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
modified	[InstanceEdit:9665432] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9665457] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665487] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9665496] Orlic-Milacic, Marija, 2019-10-31 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666692] Orlic-Milacic, Marija, 2019-11-05 [InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
normalReaction	[Reaction:1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers [Homo sapiens]
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR [Homo sapiens] [Reaction:9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9665429] R-HSA-9665408.2
summation	[Summation:9665480] RAS signaling is activated dowsntream of ERBB2 ECD mutants E...
(hasEvent)	[Pathway:9665348] Signaling by ERBB2 ECD mutants [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (9665408)