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Details on Person Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate

Class:IdReaction:9665389
_displayNameHeterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
_doReleaseTRUE
_timestamp2020-02-13 21:16:59
authored[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30
catalystActivity[CatalystActivity:9665390] protein tyrosine kinase activity of ERBB2 ECD mutants:EGF:EGFR [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9665383] Orlic-Milacic, Marija, 2019-10-30
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus[EntityFunctionalStatus:9665387] gain_of_function of ERBB2 ECD mutants:EGF:EGFR [plasma membrane]
input[Complex:9665391] ERBB2 ECD mutants:EGF:EGFR [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
modified[InstanceEdit:9665474] Orlic-Milacic, Marija, 2019-10-31
[InstanceEdit:9665496] Orlic-Milacic, Marija, 2019-10-31
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHeterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
normalReaction
output[Complex:9665380] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:9665469] Negative regulation by 'ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane]'
[NegativeRegulation:9665470] Negative regulation by 'ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane]'
releaseDate2020-03-17
reviewed[InstanceEdit:9666036] Bose, Ron, 2019-10-25
[InstanceEdit:9666034] Krishna, Anagha, 2019-10-25
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9665398] R-HSA-9665389.2
summation[Summation:9665384] ERBB2 S310F shows stronger activation of downstream signalin...
(hasEvent)[Pathway:9665348] Signaling by ERBB2 ECD mutants [Homo sapiens]
(precedingEvent)[Reaction:9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR [Homo sapiens]
[Reaction:9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 [Homo sapiens]
[Reaction:9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 [Homo sapiens]
[Reaction:9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 [Homo sapiens]
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