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Details on Person ERBB2 ECD mutants heterodimerize with EGFR

Class:IdReaction:9665388
_displayNameERBB2 ECD mutants heterodimerize with EGFR
_doReleaseTRUE
_timestamp2020-02-13 21:16:36
authored[InstanceEdit:9665383] Orlic-Milacic, Marija, 2019-10-30
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9665383] Orlic-Milacic, Marija, 2019-10-30
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus[EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
input[Complex:9665377] ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
[Complex:179847] EGF:EGFR [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
modified[InstanceEdit:9665496] Orlic-Milacic, Marija, 2019-10-31
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666690] Orlic-Milacic, Marija, 2019-11-05
[InstanceEdit:9666742] Orlic-Milacic, Marija, 2019-11-06
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9676412] Orlic-Milacic, Marija, 2020-02-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameERBB2 ECD mutants heterodimerize with EGFR
normalReaction
output[Complex:9665391] ERBB2 ECD mutants:EGF:EGFR [plasma membrane] [Homo sapiens]
[Complex:1225828] CDC37 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
[Complex:1221657] HSP90 [cytosol] [Homo sapiens]
releaseDate2020-03-17
reviewed[InstanceEdit:9666036] Bose, Ron, 2019-10-25
[InstanceEdit:9666034] Krishna, Anagha, 2019-10-25
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9665394] R-HSA-9665388.2
summation[Summation:9665386] ERBB2 extracellular domain (ECD) mutants harbor missense mut...
(hasEvent)[Pathway:9665348] Signaling by ERBB2 ECD mutants [Homo sapiens]
(precedingEvent)[Reaction:9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate [Homo sapiens]
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