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Details on Person The following ERBB2 KD mutants are resistant to lapatinib:
Class:Id Summation:9665306 _displayName The following ERBB2 KD mutants are resistant to lapatinib: _timestamp 2023-03-18 14:35:40 created [InstanceEdit:9665301] Orlic-Milacic, Marija, 2019-10-30 modified [InstanceEdit:9665331] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9831085] Orlic-Milacic, Marija, 2023-03-18 text The following ERBB2 KD mutants are resistant to lapatinib:
ERBB2 L755P (Kancha et al. 2011; Yang et al. 2015 - the L755P substitution results in a structural change that makes binding to lapatinib energetically unfavorable; Nagano et al. 2018);
ERBB2 L755S (Kancha et al. 2011, Bose et al. 2013, Cocco et al. 2018, Nagano et al. 2018);
ERBB2 D769Y (Bose et al. 2013; partial sensitivity reported by Nagano et al. 2018);
ERBB2 T798I (Trowe et al. 2008);
ERBB2 T798M (Kancha et al. 2011, Rexer et al. 2013, Hanker et al. 2017);
ERBB2 T733I (Trowe et al. 2008);
ERBB2 V842I (Bose et al. 2013, Nagano et al. 2018);
ERBB2 L869R (Hanker et al. 2017);
One study reported sensitivity of ERBB2 I767M, ERBB2 G778_P780dup and ERBB2 R896C to lapatinib (Nagano et al. 2018), while another study reported resistance (Bose et al. 2013). (summation) [FailedReaction:9665284] Resistant ERBB2 KD mutants do not bind lapatinib [Homo sapiens]
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No pathways have been reviewed or authored by The following ERBB2 KD mutants are resistant to lapatinib:
| Class:Id | Summation:9665306 |
|---|---|
| _displayName | The following ERBB2 KD mutants are resistant to lapatinib: |
| _timestamp | 2023-03-18 14:35:40 |
| created | [InstanceEdit:9665301] Orlic-Milacic, Marija, 2019-10-30 |
| modified | [InstanceEdit:9665331] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9831085] Orlic-Milacic, Marija, 2023-03-18 |
| text | The following ERBB2 KD mutants are resistant to lapatinib: ERBB2 L755P (Kancha et al. 2011; Yang et al. 2015 - the L755P substitution results in a structural change that makes binding to lapatinib energetically unfavorable; Nagano et al. 2018); ERBB2 L755S (Kancha et al. 2011, Bose et al. 2013, Cocco et al. 2018, Nagano et al. 2018); ERBB2 D769Y (Bose et al. 2013; partial sensitivity reported by Nagano et al. 2018); ERBB2 T798I (Trowe et al. 2008); ERBB2 T798M (Kancha et al. 2011, Rexer et al. 2013, Hanker et al. 2017); ERBB2 T733I (Trowe et al. 2008); ERBB2 V842I (Bose et al. 2013, Nagano et al. 2018); ERBB2 L869R (Hanker et al. 2017); One study reported sensitivity of ERBB2 I767M, ERBB2 G778_P780dup and ERBB2 R896C to lapatinib (Nagano et al. 2018), while another study reported resistance (Bose et al. 2013). |
| (summation) | [FailedReaction:9665284] Resistant ERBB2 KD mutants do not bind lapatinib [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The following ERBB2 KD mutants are resistant to lapatinib: