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Details on Person Resistant ERBB2 KD mutants do not bind lapatinib

Class:IdFailedReaction:9665284
_displayNameResistant ERBB2 KD mutants do not bind lapatinib
_doReleaseTRUE
_timestamp2019-11-12 18:17:16
authored[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9665281] Orlic-Milacic, Marija, 2019-10-30
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus[EntityFunctionalStatus:9665279] loss_of_function of ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]
input[Complex:9665276] ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
[ChemicalDrug:1216521] Lapatinib [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9646493] Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study
[LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
[LiteratureReference:9646787] Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
[LiteratureReference:9646776] EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
[LiteratureReference:9652195] Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2
[LiteratureReference:9647026] An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
modified[InstanceEdit:9665321] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9667497] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameResistant ERBB2 KD mutants do not bind lapatinib
normalReaction
releaseDate2019-12-10
reviewed[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9665295] R-HSA-9665284.2
summation[Summation:9665306] The following ERBB2 KD mutants are resistant to lapatinib:
(hasEvent)[Pathway:9665251] Resistance of ERBB2 KD mutants to lapatinib [Homo sapiens]
(updatedInstance)[_UpdateTracker:9835738] Update Tracker - [FailedReaction:9665284] Resistant ERBB2 KD mutants do not bind lapatinib - v85:[modifyText]
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